• Prof. med. Fabian Geisler (PI)
• Simone Jörs (Dipl.-Biol., Post-Doc)
• Dr. med. Marc Ringelhan
• Stephanie Dürl (Dipl.-Biol., BTA)

Our group investigates the function of various intracellular signalling pathways that regulate development, homeostasis, and regeneration of the liver. The NF-B- and the Notch-pathway are central signalling pathways that control essential processes like proliferation, differentiation, and apoptosis. Using different molecular in vivo and in vitro systems we focus on studying NF-B signalling in liver inflammation, apoptosis, and regeneration. In close cooperation with AG Siveke we further seek to characterize the role of Notch-signalling in liver and bile duct development and its role in regulation of embryonic and adult liver progenitor cell growth.

1. Geisler F and Strazzabosco M. Emerging roles of Notch signaling in liver disease. Hepatology (2015) 61(1):382-392.
2. Jeliazkova P, Jors S, Siveke JT and Geisler F. On the role of Notch1 and adult hepatocytes in murine intrahepatic cholangiocarcinoma development. Hepatology (2013) 58(5):1859-1860.
3. Jeliazkova P, Jors S, Lee M, Zimber-Strobl U, Ferrer J, Schmid RM, Siveke JT and Geisler F. Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1. Hepatology (2013) 57(6):2469-2479.
4. Ringelhan M, Schmid RM and Geisler F. The NF-kappaB Subunit RelA/p65 Is Dispensable for Successful Liver Regeneration after Partial Hepatectomy in Mice. PLoS One (2012) 7(10):e46469.
5. Xing X, Burgermeister E, Geisler F, Einwachter H, Fan L, Hiber M, Rauser S, Walch A, Rocken C, Ebeling M, Wright MB, Schmid RM and Ebert MP. Hematopoietically expressed homeobox is a target gene of farnesoid X receptor in chenodeoxycholic acid-induced liver hypertrophy. Hepatology (2009) 49(3):979-988.
6. Geisler F, Nagl F, Mazur PK, Lee M, Zimber-Strobl U, Strobl LJ, Radtke F, Schmid RM and Siveke JT. Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice. Hepatology (2008) 48(2):607-616.
7. Geisler F, Algul H, Paxian S and Schmid RM. Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro. Gastroenterology (2007) 132(7):2489-2503.
8. Algul H, Treiber M, Lesina M, Nakhai H, Saur D, Geisler F, Pfeifer A, Paxian S and Schmid RM. Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. J Clin Invest (2007) 117(6):1490-1501.
9. Geisler F, Algul H, Riemann M and Schmid RM. Questioning current concepts in acute pancreatitis: endotoxin contamination of porcine pancreatic elastase is responsible for experimental pancreatitis-associated distant organ failure. J Immunol (2005) 174(10):6431-6439.
10. Iozzo P, Lautamaki R, Geisler F, Virtanen KA, Oikonen V, Haaparanta M, Yki-Jarvinen H, Ferrannini E, Knuuti J and Nuutila P. Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver. Diabetologia (2004) 47(7):1149-1156.

Medical theses

Interested medical students please drop by the experimental laboratory or send an email.
 

Grant support

• Deutsche Forschungsgemeinschaft
• Else-Kröner-Fresenius-Stiftung
• Kommission für klinische Forschungsprojekte (KKF) TUM